diff --git a/scripts/langindex.json b/scripts/langindex.json
index 5c2eb5227..2b2ebb48f 100644
--- a/scripts/langindex.json
+++ b/scripts/langindex.json
@@ -432,6 +432,7 @@
   "addon.mod_assign.overdue": "assign",
   "addon.mod_assign.submission": "assign",
   "addon.mod_assign.submissioneditable": "assign",
+  "addon.mod_assign.submissionempty": "assign",
   "addon.mod_assign.submissionnoteditable": "assign",
   "addon.mod_assign.submissionnotsupported": "local_moodlemobileapp",
   "addon.mod_assign.submissionslocked": "assign",
diff --git a/src/addons/mod/assign/lang.json b/src/addons/mod/assign/lang.json
index 6806d8ad0..fa94b86fc 100644
--- a/src/addons/mod/assign/lang.json
+++ b/src/addons/mod/assign/lang.json
@@ -84,6 +84,7 @@
     "overdue": "Assignment is overdue by: {{$a}}",
     "submission": "Submission",
     "submissioneditable": "Student can edit this submission",
+    "submissionempty": "Nothing was submitted",
     "submissionnoteditable": "Student cannot edit this submission",
     "submissionnotsupported": "This submission is not supported by the app and may not contain all the information.",
     "submissionslocked": "This assignment is not accepting submissions",
diff --git a/src/addons/mod/assign/pages/edit/edit.ts b/src/addons/mod/assign/pages/edit/edit.ts
index d11712cd6..5949a7446 100644
--- a/src/addons/mod/assign/pages/edit/edit.ts
+++ b/src/addons/mod/assign/pages/edit/edit.ts
@@ -398,6 +398,10 @@ export class AddonModAssignEditPage implements OnInit, OnDestroy, CanLeave {
             throw Translate.instant('addon.mod_assign.acceptsubmissionstatement');
         }
 
+        if (AddonModAssignHelper.isSubmissionEmptyForEdit(this.assign!, this.userSubmission!, inputData)) {
+            throw Translate.instant('addon.mod_assign.submissionempty');
+        }
+
         let modal = await CoreLoadings.show();
         let size = -1;
 
diff --git a/src/addons/mod/assign/services/assign-helper.ts b/src/addons/mod/assign/services/assign-helper.ts
index c191c8013..8c5d55b35 100644
--- a/src/addons/mod/assign/services/assign-helper.ts
+++ b/src/addons/mod/assign/services/assign-helper.ts
@@ -237,6 +237,31 @@ export class AddonModAssignHelperProvider {
         return true;
     }
 
+    /**
+     * Check whether the edited submission has no content.
+     *
+     * @param assign Assignment object.
+     * @param submission Submission to inspect.
+     * @param inputData Data entered in the submission form.
+     * @returns Whether the submission is empty.
+     */
+    isSubmissionEmptyForEdit(
+        assign: AddonModAssignAssign,
+        submission: AddonModAssignSubmission,
+        inputData: CoreFormFields,
+    ): boolean {
+        const anyNotEmpty = submission.plugins?.some((plugin) =>
+            !AddonModAssignSubmissionDelegate.isPluginEmptyForEdit(assign, plugin, inputData));
+
+        // If any plugin is not empty, we consider that the submission is not empty either.
+        if (anyNotEmpty) {
+            return false;
+        }
+
+        // If all the plugins were empty (or there were no plugins), we consider the submission to be empty.
+        return true;
+    }
+
     /**
      * List the participants for a single assignment, with some summary info about their submissions.
      *
diff --git a/src/addons/mod/assign/services/handlers/default-submission.ts b/src/addons/mod/assign/services/handlers/default-submission.ts
index e78516b57..2365c122e 100644
--- a/src/addons/mod/assign/services/handlers/default-submission.ts
+++ b/src/addons/mod/assign/services/handlers/default-submission.ts
@@ -50,6 +50,17 @@ export class AddonModAssignDefaultSubmissionHandler implements AddonModAssignSub
         return true;
     }
 
+    /**
+     * @inheritdoc
+     */
+   isEmptyForEdit(
+       assign: AddonModAssignAssign, // eslint-disable-line @typescript-eslint/no-unused-vars
+       plugin: AddonModAssignPlugin, // eslint-disable-line @typescript-eslint/no-unused-vars
+       inputData: CoreFormFields, // eslint-disable-line @typescript-eslint/no-unused-vars
+    ): boolean {
+        return true;
+    }
+
     /**
      * @inheritdoc
      */
diff --git a/src/addons/mod/assign/services/submission-delegate.ts b/src/addons/mod/assign/services/submission-delegate.ts
index 872fe75f1..f50e718fc 100644
--- a/src/addons/mod/assign/services/submission-delegate.ts
+++ b/src/addons/mod/assign/services/submission-delegate.ts
@@ -62,6 +62,20 @@ export interface AddonModAssignSubmissionHandler extends CoreDelegateHandler {
         plugin: AddonModAssignPlugin,
     ): boolean;
 
+    /**
+     * Check if a plugin has no data in the edit form.
+     *
+     * @param assign The assignment.
+     * @param plugin The plugin object.
+     * @param inputData Data entered by the user for the submission.
+     * @returns Whether the plugin is empty.
+     */
+    isEmptyForEdit?(
+        assign: AddonModAssignAssign,
+        plugin: AddonModAssignPlugin,
+        inputData: CoreFormFields,
+    ): boolean;
+
     /**
      * Should clear temporary data for a cancelled submission.
      *
@@ -502,6 +516,22 @@ export class AddonModAssignSubmissionDelegateService extends CoreDelegate<AddonM
         return this.executeFunctionOnEnabled(plugin.type, 'isEmpty', [assign, plugin]);
     }
 
+    /**
+     * Check if a plugin has no data in the edit form
+     *
+     * @param assign The assignment.
+     * @param plugin The plugin object.
+     * @param inputData Data entered in the submission form.
+     * @returns Whether the plugin is empty.
+     */
+    isPluginEmptyForEdit(
+        assign: AddonModAssignAssign,
+        plugin: AddonModAssignPlugin,
+        inputData: CoreFormFields,
+    ): boolean | undefined {
+        return this.executeFunctionOnEnabled(plugin.type, 'isEmptyForEdit', [assign, plugin, inputData]);
+    }
+
     /**
      * Prefetch any required data for a submission plugin.
      *
diff --git a/src/addons/mod/assign/submission/file/services/handler.ts b/src/addons/mod/assign/submission/file/services/handler.ts
index 595572d4d..838c26a1e 100644
--- a/src/addons/mod/assign/submission/file/services/handler.ts
+++ b/src/addons/mod/assign/submission/file/services/handler.ts
@@ -61,6 +61,15 @@ export class AddonModAssignSubmissionFileHandlerService implements AddonModAssig
         return files.length === 0;
     }
 
+    /**
+     * @inheritdoc
+     */
+    isEmptyForEdit(assign: AddonModAssignAssign): boolean {
+        const currentFiles = CoreFileSession.getFiles(ADDON_MOD_ASSIGN_COMPONENT, assign.id);
+
+        return currentFiles.length == 0;
+     }
+
     /**
      * @inheritdoc
      */
diff --git a/src/addons/mod/assign/submission/onlinetext/services/handler.ts b/src/addons/mod/assign/submission/onlinetext/services/handler.ts
index ac88ded41..73a5b318d 100644
--- a/src/addons/mod/assign/submission/onlinetext/services/handler.ts
+++ b/src/addons/mod/assign/submission/onlinetext/services/handler.ts
@@ -58,6 +58,29 @@ export class AddonModAssignSubmissionOnlineTextHandlerService implements AddonMo
         return text.trim().length === 0;
     }
 
+    /**
+     * @inheritdoc
+     */
+    isEmptyForEdit(
+        assign: AddonModAssignAssign,
+        plugin: AddonModAssignPlugin,
+        inputData: AddonModAssignSubmissionOnlineTextData,
+     ): boolean {
+        const text = this.getTextToSubmit(plugin, inputData);
+
+        if (CoreText.countWords(text) > 0) {
+            return false;
+        }
+
+        // Check if the online text submission contains video, audio or image elements
+        // that can be ignored and stripped by count_words().
+        if (/<\s*((video|audio)[^>]*>(.*?)<\s*\/\s*(video|audio)>)|(img[^>]*>)/.test(text)) {
+            return false;
+        }
+
+        return true;
+     }
+
     /**
      * @inheritdoc
      */